Sorted by franchises (sorted by total units sold):
franchise/number of titles/units sold/Average units per title
Mario - 18x - 51,974,078 - 2,887,449
Pokemon - 9x - 38,625,561 - 4,291,729
*Wait a second, where's Pokemon Yellow? They forgot about that one, it sold 3.16 million according to VGC.
Dragon Quest - 12x - 30,834,582 - 2,569,549
Final Fantasy - 10x - 23,935,358 - 2,393,536
DS Training Series - 5x - 13,787,716 - 2,757,543
NES Sports Series - 7x - 12,820,000 - 1,831,429
Wii Series - 3x - 8,639,000 - 2,879,667
Tetris - 2x - 6,040,000 - 3,020,000
Donkey Kong - 2x - 5,200,000 - 2,800,000
Gran Turismo - 3x - 5,085,085 - 1,695,028
Street Fighter - 2x - 4,980,000 - 2,490,000
Animal Crossing - 1x - 4,743,000
Monster Hunter - 2x - 4,138,387 - 2,069,194
Yu-Gi-Oh! - 2x - 3,763,134 - 1,881,582
Super Smash Bros. - 2x - 3,313,055 - 1,656,528
*VGC has Brawl and the original considerably higher. Also Melee is at 1.45 million in Japan.
Zelda - 2x - 3,300,000 - 1,650,000
*According to VGC OoT sold 1.46 million in Japan.
Kirby - 2x - 3,110,000 - 1,555,000
Resident Evil - 1x - 2,154,975
Mah-Jong - 1x - 2,130,000
Chronno Trigger - 1x - 2,030,000
Nintendogs - 1x - 1,779,603
Hot Shots Golf - 1x - 1,777,895
Derby Stallion - 1x - 1,737,819
Mana - 1x - 1,500,000
Dragon Ball - 1x - 1,450,000
Virtua Fighter - 1x - 1,417,034
I've left out some cause I'm tired, but they were only games with 1 entry and selling low.
Interesting facts:
Mario is the best selling franchise.
Pokemon is the franchise with more than 1 game, with the more units/title sold.
DQ series > FF series in units sold.
DQ series > FF series in average untis/title sold.
Proud poster of the 10000th reply at the Official Smash Bros Update Thread.
tag - "I wouldn't trust gamespot, even if it was a live comparison."
Bets with Conegamer:
Pandora's Tower will have an opening week of less than 37k in Japan. (Won!)
Pandora's Tower will sell less than 100k lifetime in Japan.
Stakes: 1 week of avatar control for each one.