1. Cave Story

2.Pokemon(any, except for Black)

3. Super Street Fighter 4

4. Fallout 3

5. Animal Crossing: New Leaf

6. Wipeout(not the TV show, the racing game)

7. Ratchet and Clank(I really enjoyed Size Matters)

8. God of War

9. Mario(for god's sake, how can you have possible never played a Mario game?)

10. Super Smash Bros 4.

11. Legend of Zelda- good choices is the original, Twilight Princess, Link between World, and Wind Waker are 8/8

12. Castle Crashers

13. Final Fantasy( I enjoyed XI and X a lot)

14. Kingdom Hearts

15. Professor Layton( plot is great, puzzles are pleasant. The 2 trilogies never took a step back or ruined the franchise)

16. Ace Attorney

17. Megaman( Star force is 50/50 within the community; go for any other Megaman game)

18. GTA series(just go for 5, it has the most content)

19. Shovel Knight

20. Donkey Kong Country

21. Patapon(only first 2- third was cancer)

22. Tetris- evaluate your life if you never played this game before

23. Kirby: Amazing Mirror(20th anniversary edition is nice as well)

24. Half-Life

25. Pac man

26. Cory in the House: DS edition

27. The Witcher series

28. Resident Evil

29. Zone of the Enders: Second Runner

30.Xenoblade Chronicles

31. Spyro trilogies

32. Crash trilogies

33. Uncharted

34. Dark Souls

35. Metal Gear solid(try the first one)

36. Life is Strange

37. Batman games( Arkham City was amazing)

38. Mass Effect

39. Metroid Prime trilogy

40. Undertale

41. Bioshock( infinite was great)

42. Super Mario Galaxy/Super Mario Sunshine/ Super Mario 64

43. Portal 2

44. Borderlands

45. Diablo 2

46. Plants VS Zombies(don't play the second one- you'll regret it)

47. Tekken 3

48. Need for Speed

49. Silent Hill 

50.

Just thought I'd spark a list for some amazing games out there that you may have missed out on. 

I'd love to make this a continous thread for VGChartz, to allow people to explore the list and check out the series/games listed. 

Also, note the numbers don't have any meaning as to which is better. I just put the numbers to list the spot the game appears on the list- this helps keep it organized.

Tagged

Any Souls game, obviously

Any Witcher

Resident Evil (reremake, 2 & 4 imho)

ZONE OF THE ENDERS THE SECOND RUNNER!!!

I'd add Xenoblade Chronicles, the other R&C games, and the original Spyro/Crash trilogies in addition to those already on your list. 

Decent thread but it's all about personal taste and opinion. Some people won't agree with everybodies choices, but here's what I consider must plays.

Trails in the sky
Shining force 3 trilogy
Danganronpa series
Uncharted series
Quack shot
Life Is Stange
Final Fantasy series
Fallout 3
Ratchet and clanks
Demon souls
Dark souls 1
Metal gear solid 1
Mass effect series

I'll recommend 2 trilogies, metrod prime and crash bandicoot.

Undertale, because Undertale. Also, no spoilers allowed.

Paper Mario, this game really goes to show how a bit of simplicity and personality coupled with great game design can make something very special, also this basically goes for Undertale too, but multiply it tenfold and there you go.

Paper Mario: The Thousand Year Door, this is an excellent example of how to make a great sequel, not quite as charming as the first one though, but just as excellent.

Super Paper Mario, great story with amazing concepts and ideas blended with decent enough gameplay, the main reason to play this is to see how deep you can go into something as originally bland as Mario and still create something incredibly memmorable even if it's very flawed or not very inspiring.

Super Mario 64, how the 3D platformer started, it basically should be used as base of any game of the genre.

Super Mario Sunshine, dem controls are the finest thing I've ever felt, more Mario games should control this way, this is how you take the 3D platformer to the next level by making it felt super smooth and extremely acrobatic.

Super Mario Galaxy, incredible atmosphere, great game design, a very enjoyable trip, a bit flawed with the motion controls segments, but aside from that, everything is just perfect.

Crash Bandicoot 2, this is the textbook defenition of making your game have its own personality, once you hear people say "that track sounds like something out of Crash" you know you've done something right. That aside, apart from a few questionable design choices, the game is perfect, and its difficulty is incredibly balanced. It's also basically the most fun game 100% ever, so that counts for something, I guess.

Kingdom Hearts 2 Final Mix, great music, great controls, great combat, amazing boss battles, entertaining story, all blended with a nice cup of Disney nostalgia, what more could ya want?

Portal 2, play it on one sitting blindly and see what it does to you.

Super Mario Bros 3, just like SM64, this the base that all 2D platformers shoud build around.

Bioshock Infinite, some of the most memmorable moments in gaming, a flawless art direction and a game world that you can practically breathe make this something that you have to experience.

Regarding games and movies it's close to impossible for me to pick my favorites overall so I'll list my favorite game in each genre.

RTS: Command & Conquer: Tiberian Sun
TBS: Heroes of Might and Magic 3 (Civilization V close 2nd)
Puzzle: Portal (Portal 2 close 2nd)
Multiplayer: The Last of Us
TPS: Plants vs Zombies: Garden Warfare (The Last of Us close 2nd)
FPS: Borderlands (Bioshock close 2nd)
JRPG: Pokémon Silver
WRPG: Fallout 3
TRPG: Valkyria Chronicles
ARPG: Diablo 2
3D Platformer: Super Mario Galaxy
2D Platformer: Donkey Kong Country Returns (Wario Land close 2nd)
Brawler: Super Smash Bros. Wii U
Karting: Crash Team Racing (Sonic & All-Star Racing Transformed close 2nd)
Action game: Assassin's Creed 2 (Dead Rising close 2nd)
Open world: Grand Theft Auto: San Andreas (Red Dead Redemption close 2nd)
Horror: SOMA (Resident Evil close 2nd)
Fighting: Tekken 3
Arcade racing: Need for Speed: Underground 2
Sim racing: Gran Turismo 1
Sports: Sensible Soccer (haven't enjoyed any modern sports game as much as I enjoyed playing this on my Game Boy)
Simulation: Minecraft
Motion-controlled: Sports Champions 2
MMO: None

Danganronpa 1 and 2
Ace Attorney 1-3 (at least! If possible, all of them)
Super Mario RPG
Chrono Trigger
Grandia 2
Undertale
Super Mario 3
Super Mario World
Sonic 2 or 3
Metal Slug (preferably 3)
Earthbound
Fatal frame 4
Silent Hill 2
Power Stone 2
Paper Mario: The Thousand Year Door

..and that's all I got so far.