Going by the cover art, my guess is that it's the next Star Fox game :D (or so I hope) . We'll just have to wait and see.

Does anybody have any idea of what else it could be? 

Edit: LOL, just saw this news already posted in another thread >_< . Sorry XD . 

I guess is Metroid Other M with some new material to show.
I don't think is a new Starfox Tittle, but who knows...

It looks so much like Star Fox, but I really don't want to get my hopes up in vain.

Maybe it is the next Zelda game with the title 'The Legend of Zelda: Mario Galaxy Edition'

- "one of gaming’s most recognizable heroes"

- a picture of space

Could this be related to this news: http://www.joystiq.com/2010/04/27/mega-man-universe-trademark-filed-by-capcom/ ??!

I don't even want to think that could be the case : that would be way too awesome :O...

kid icarus!!!!!!!!

From the picture we have:

Stars

Possibly the Vulpecula constellation aka the FOX

Gas CLOUDs

Only one possible answer........







............ Madworld 2

lets investigate this shit

the only thing that worries me is that they only mention one big title. Are they not going to have Nintendo's entire e3 lineup?

If I connect all the brightest stars I get...... ummmmm.... XD oh, looks like a Kangaroo.... (ponders) Hmmmmmmmm...... Pyro as Bill, I think you're onto something with it being Madworld 2... .