I can't believe no one has brought up the point that MH3 requires a paid subscription to play online in Japan. One cannot directly compare sales of this game to other RPGs without also accounting for online income. The fact that it has a paid subscription model probably definitely hurts the overall sales that it could have had in Japan otherwise.
I think MH3 will sell very well in the US, especially with the sleek bundle that it is coming in.
Most anticipated games of 2011:
Uncharted 3,Legend of Zelda: Skyward Sword, Rocksmith
Modern Warfare 3, Super Mario 3D