I made this thread last year, and it was reasonably popular. Nobody's made one for this year, so it's a little late, but I'll make it.
I'll start off with a few, and add more later on. Everybody feel free to predict and evaluate my predictions, or the predictions of other posters.
Predictions can be related to sales, gaming, VGC, anything like that.
So, I'll start off with hardware predictions.
1) Wii: 84 million
2) X360: 48 million
3) PS3: 43.5 million
4) PSP: 63 million
5) DS: 155 million
6) PS3 will outsell 360 for the year
7) God of War III will launch to over 800k sales.
8) Heavy Rain will sell under 200k first week (I want to be wrong here)
9) Halo Reach will top 3 million first week
10) NATAL will perform better than PSMotion/GEM/Whatever it's called
11) Resistance 3 will launch in 2010's holiday season
12) FF Versus XIII will not launch in the west in 2010
13) GT5 will sell around 2.5 million first week
14) GT5 will be the highest-selling PS3 game of the year
15) Halo Reach will be the highest-selling X360 game of the year
16) Not counting Wii Sports, Wii Sports Resort will be the highest-selling Wii game of the year
17) There will be another large update (like VGC 2.0) in the first half of 2010.
18) No PSP games will sell over 3 million units for the year.
19) FF13 on PS3 will have outsold the 360 version 2:1 by year's end.
20) The Last Guardian will be the best reviewed game in the series, going by Metacritic (91 to beat)
I'll add more later.