FIFA11 for sure!!!

Rage?

Guitar Hero Van Halen could be a 50/50 bet

I hope that Bayonetta will hit 1m week 1 worldwide, and 2,8 m lifetime in X360

Alpha Protocol? The preorders are fairly high.

EDIT: Oh, and Red Dead Redemption.

Sonic & SEGA Racing all-stars might sell if its bundled like SEGA Tennis
Madden 11 easilyhttp://www.vgchartz.com/forum/thread.php?id=97016&page=1#
Aliens vs Predator hopefully
Battlefield Bad Company 2 easily
Prince of Persia: The Forgotten Sands might sell if the movie does well
UFC 2010 easily
Max Payne hopefully
Batman: Arkham Asylum 2 easily
Medal of Honor maybe
MGS Rising easily

Metal Gear Solid Rising, If its released this year that is. Or are you just listing ones with confirmed release dates?

yeah there are many 1m contenders this year.

100%:

Splinter Cell: Conviction
Mass Effect 2
Call of Duty 7
Halo Reach
Fable III
Bioshock 2
Fifa 11
Madden 11
Battlefield Bad Company 2
Red Dead Redemption
UFC Undisputed 2010


Very Likely:

Alan Wake
Bayonetta
Fallout: New Vegas
Crackdown 2
Final Fantasy XIII
Lost Planet 2
Dead Rising 2
Rage
Brink
Mafia II
Max Payne 3
Metal Gear Solid Rising
Star Wars Force Unleashed 2
Batman Arkham Asylum 2
Army of Two 40th Day
EA Sports MMA
Medal of Honor

Likely:

Dante's Inferno
Dead Space 2
Castlevania Lords of Shadow
Alpha Protocol
Singularity
Aliens Colonial Marines


Maybe:

Metro 2033
Aliens vs Predator (I still can't imagine that Rebellion make a decent game this gen for consoles)
Prince of Persia: The Forgotten Sands
MechWarrior
Kingdom Under Fire II
Darksiders
PES 2011 (only if it's good this time)

Note: I only listed the games I think have a shot at reaching 1m before 2011. It's not my fault if certain games don't appear in 2010 :P
Oh and I know I have no recent or older games on that list. Too lazy to do some research :)

Bayonetta and Dante's Inferno are selling pretty bad, doesnt look like they're going to pass 1 million. Will metro 2033 suffer the same fate?

New Valve game.
Valve release game every year.