Mass Effect 2
Bioshock 2
Fable 3 (if it comes out in 2010)
3D Dot Game Heroes
No More Heroes Desperate Struggle

1. Bioshock 2
2. Half-Life 2: Episode 3 (If it releases in 2010)
3. Starcraft 2
4. Mass Effect 2
5. Red Dead Redemption

1. Bayonetta (xbox360)

2. Mass Effect 2

3. Bioshock 2

4 Aliens vs Predator

5. Kingdom under fire 2

Capcom if your listening, we need a Powerstone 3 now!!!!!!!!!!!!!

1. Final Fantasy XIII (PS3)

2. Red Dead Redemption (PS3)

3. Mass Effect 2 (360)

4. God of War III (PS3)

5. Napoleon Total War (PC)

This is basically just a list for the 1st half, there is too much uncertainty about what games will come later in the year

1. Final Fantasy XIII

2. Gran Turismo 5

3. God of War III

4. Monster Hunter 3

5. Phantasy Star Portable II

1. Gran Turismo 5 (PS3)

2. Super Mario Galaxy 2 (Wii)

3. F1 2010 (PS3)

4. Agent (PS3)

5. Wii Vitality/WiiRelax (Wii)

1. God of War 3 (PS3)
2. White Knight Chronicles (PS3)
3. The Last Rebellion (PS3)
4. GT5 (PS3)
5. Ar Tonelico 3 (PS3)= I hope NIS gets it right this time

Worthy mentions: Heavy Rain, Yakuza 3, MAG, 3D Dot Game Heroes.
If they release in 2010: FF VS XIII, Agent, KH3 would be sweet.
PS3 owners seem to be in for a real treat in 2010 moreso than 2009

1. God of War 3 (PS3)
2. Mass Effect 2 (360)
3. Gran Turismo 5 (PS3)
4. Halo:Reach (360)
5. Bioshock 2 (PS3/360)

1. Mass Effect 2
2. Alan Wake
3. Halo: Reach
4. Splinter Cell: Conviction
5. Bioshock 2

1. Final Fantasy XIII
2. God of War III
3. Halo Reach
4. Crackdown 2
5. Gran Turismo 5

Although there's basically no difference between spot 1 and spot 15
Heavy Rain, Mafia 2, Splinter Cell Conviction, Crysis 2, Fable 3 etc. you know.