The only problem I could see with the Wii version is some of the AI for choosing which characters to pick to fit your evolution and the online stuff... I mean, the whole being able to download monsters that looks like anything seems anti-nintendo, what with all the 12 year olds making penis monsters.
The graphics... might be a problem, but I would doubt it considering how long they've been working on this game, and i don't think the specs have ever been speculated to be to demanding. This is a game that's meant to sell to everyone with a PC, not the graphic whore FPS crowds.
Wright probably made the comments about the 360 and PS3 though because the game is likely going to be a pain in the butt to modify so it's fun for 360 and PS3. Games with a pointer arrow are never any fun on consoles.
I mean, has their ever been a fun RTS game on a console?