Egypt would be cool, seeing Drake in front of the Great Pyramids and the Sphinx would truly be legendary....of course, like most of you said they should keep it diverse, which is where Cairo comes in. They could easily use that city as a secondary location in the game.

A Europeon city would be awesome too. Paris would be cool, someone else said the Vatican which is awesome and another person said Ancient Greece which is also a mindblowing idea. There are so many possibilities, I can't wait for U3.

Do you guys think it will come out for PS3 or PS4?

With the PS3's life span not even halfway over (and the fact that I own a PS3 and not a PS4) I'm hoping it would be for the PS3.  Naughty Dog has the engine in place and it's still pretty damned impressive.  Keep using it!  It could be like the Tomb Raider series from the PS1, where a new one comes out every couple of years, except this time, not suck.

Uncharted 3- Egypt

Uncharted 4- Lost City of Atlantis (lots of in water gameplay, maybe a boat chasing scene)

Uncharted 5- The Search for the Holy Grail

i second this

Europe with the treasure of the templars, India and the kingdom of priest John, easter island and whatever,... there are so many possibilities... I want MOAR Uncharted !

Atlantis!

Why did nobody think of that until just now?!

Atlantis would be ace!

Lara did it.

Im never buying another Tomb Raider game ever again.

Ever!

the only thing i ask of Uncharted 3 is that they have split screen

I say go with multiple locations like this one... and perhaps something with the lost city of atlantis :p