I am holding out hope that the "Next Big Thing" stop being talk of how a release on the PS3 is suddenly going to be a game changer, and people just start to enjoy PS3 games, without acting like nutty fanboys.

Uncharted is probably the only game I could see as the next big thing.

Just because we want the "Next Big Thing" doesn't mean we don't enjoy PS3 games.

New IP's, duh. They will always bring new IP's.

Some new IP that will blow everyone's minds? =O

We need some more new IP's coming out of Sony's wazoo. Fortunately, their wazoo is pretty productive so we'll see plenty more.

Final fantasy versus XIII?

Really? well I guess he wasn't lying or exaggerating

The Last Guardian will be epic

ModNation Racers
GT5
Singstar Micheal Jackson
Heavy Rain if it catches on in Europe.

The only three "big things" that I see that can really change the game for PS3 are a PS3slim+price cut, GT5 and The Agent, and the last only if it is marketed good enough.
Actually, I don't know the effect that Final Fantasy XIII and Versus can have on the PS3, I mean, yes, XIII isn't exclusive anymore, but it will sell a lot more PS3 units than 360 units (according to nielsen's survey of most-wanted games in america, which placed PS3's FFXIII above 360's, the one with ODST at the top, GOW3 second etc, can't find the link), not to mention the game's effect on the Japanese market, and maybe even in Europe.