Uncharted beats InFamous in all areas but length.

Uncharted by far.

Uncharted, it is just such a good game, and U2: AT is going to be even better

Uncharted

Uncharted, without a doubt. More replay value, fewer glitches, better graphics. The two are pretty much tied in story and gameplay, imo. Also, of course, there is Uncharted 2.

inFamous is still awesome though.

Uncharted has better graphics, better gameplay and story but the game is only 8-9 hours long while inFamous is about 25 hours long and it has bigger replay value

Uncharted wins this one.

i have both and id say uncharted is alot better.

Uncharted is by far better, but I always think Naughty Dog games are better than all the others so...

That said inFamous is still awesome.

I'll tell you once both have sequels released!

As individual games I enjoyed Uncharted more overall, but both I believe are very good titles.