Which is the better franchise?

Really hard to choose.

Both awesome.

But I choose demon souls!

Is Demon Souls really that good?

It's a tight competition but Uncharted is closer to perfection.

Between the two I would call Uncharted better because I feel Uncharted was better than Infamous, and since you specifically asked about franchises I know that Uncharted 2 looks great, I don't know if Infamous 2 is even planned (other than the ending to Infamous leading one to assume that).

DEMONS SOULS

I believe it's a safe assumption that Infamous 2 will be made with the cliffhanger and the sales of Infamous. I suppose since I asked for the better franchise it's a bit biased of a question because Uncharted 2 is well on its way and looks great while Infamous itself was released not too long ago.

Personally, I feel Uncharted compared to Infamous is much more polished.

Uncharted, but inFamous is great too

uncharted 2 blows infamous out of the water...so uncharted is the better franchise.

Uncharted, hands down