Wii Sports Resort and Motion +, Pikmin 3, Mario & Luigi 3, Zelda: Spirit Tracks, Metroid Prime Trilogy, Pokemon Heart Gold & Soul Silver. These games I'm pretty damn sure they will show at the conference. Possibly some trailers, and new info. Maybe give M&L3 a name at the end of it like SSS, and PiT had.
They will also reveal at least most of what will be coming out before Christmas (they might leave one game a surprise for later, but who knows)
Sin & Punishment 2, Mario & Sonic 2, Wario Ware: Myself! are already announced.
I expect them to announce Mario Party 9. That is pretty inevitible. 8 came out 2 years ago, and I do know that the DS one only came out a year and a half ago, but It looks like they might be making one every 2 years now, but you can't consider 2 games to be a pattern. Pikmin 3 like I mentioned earlier, Miyamoto announced it last year because he knew everyone was disappointed with the show, and it was confirmed that what Miyamoto mentioned was NOT part of New Play Control series. Star Fox Wii, I hope it'll be there. I really do. If it is, that would be a miracle. Kirby Wii was in the Japanese release list (again anyway) Will we see it at E3? I hope so!
Zelda Wii. Not gonna be announced. Don't ask for it, don't expect it. It WILL come though, just not this year. They have Zelda Spirit Tracks this year. They will have Zelda Wii at E3 next year. Possibly even announce it at GDC like they did with Spirit Tracks. Who knows.
3rd party games that will/ most likely be there(maybe not at Nintendo's conference, but we don't know, they could be): The Conduit, Red Steel 2, No More Heroes Desperate Struggle. I'm looking forward to all 3! :D
I hope they will announce some VC/WW/and DSi Ware stuff. Not release dates, just announcing a few games will be great for me. I want Super Mario Kart and SSB released on the VC (SSB is out in Japan and SMK was rated by the OFLC. I also want Star Fox. I don't think we will ever see Earth Bound, but I'm not interested in that.
Hopefully some WW and DSi Ware stuff will be announced too.