No. It will not happen anytime in the near future. 3rd party games are never as popular as Nintendo published games. On other consoles, there are too many 3rd party games for one to just rise that far ahead. Call Of Duty 4 and GTA IV is the most popular 3rd party games right now and neither is even close to getting to 10 million in one region. Now GTA:SA did come very close selling 8.72 million and 8.27 million in North America and "Others" respectively. And Vice City sold 8.2 million in North America.
Now that was on the PS2 which had an enormous installed base. The Wii will have the biggest base this generation and while I believe 3rd party games can sell very well, it's too much to expect that one game would be able to sell that much.
I'll come up with something better eventually...








