Easy: Donkey. And in the morning, He's making waffles!

I love how so many are saying "Hale, since he can heal" as if Marcus doesn't do that by hiding for 2 seconds.

@Snesboy: The main character of Gears of War.

I'm definitely going with Marcus, as he can take several headshots with light and medium weapons without a hitch. Then he'd whack Hale to the ground with a Boomshot, climb onto his fallen body, rip his arms off and beat him to death with them

Hale can't heal when he gets sawed in half.

Marcus Fenix all the way. If he can kill General Raam, what makes you think he can't kill a Chimera and/or Chimera Hybrid?

Hale, not Drake.
Anyways, I'm not really sure. Depends on the extent of the powers the Chimeran virus has given him (besides regeneration).

Um.... Hale is faster, stronger, and more vital than a normal human (Marcus is a normal human) because of the Chimeran virus that he got effected with. He also regens (and not game regen to make the game easier. No story regen.)

Nathan Hale.

Why?:

Because marcus has a chainsaw on his gun..... that's not fair at all........

Clearly Zebra.

Zebra lives with a Lion! He lives his life on the EDGE!! Donkey lives with a 8ft ogre than pretty much watches his back all the time.....

Ryu Hayabusa. He takes rockets, missiles, bullets, thunder, ice, fire, cuts, slashes, chainsaws(the zombies, remember?) and just about anything and everything, AND has regenrating health.

oh, but between Marcus and hale, I already said. 

Nathan Hale. If you had said Marcus Fenix it might be different. Unless Sack Boy helps out or the hero or heroine from Heavy Rain...I forgot Nathan has Solid Snake on his side, so I say Nathan.

Nathan Hale would destroy fenix, you have a normal human in gears Vs Hale who is a super human.