#40 - Hint: It's out third trip and we're going down under!
Supplementary Hint: This series is a spin-off of another series but became more popular than the original with it's large openworld.
Supplementary Hint 2: There are many upgrades in this game that can help you race to success.

#38 - Hint: This open-world title is set in rural USA.
Supplementary Hint: This series of games continues to be very formulaic to this day.

#37 - Hint: Scoring goals a lot faster than Fifa!

More hints!

43) This game likes reversing things. Names, structures... It also has an overly convoluted spell system. When you think you've reached the end you might be in for a suprise

41) Get to the top of the mountain.

40) Unusual to this series and JRPGs in general, the MC of this game can wield not one but three weapon types

39) Despite being released in the same year its console was replaced, it might be the game people most associate with it

38) This series is seemingly well on its way to remaking all its games from the beginning. This was the second remake

37) ^Strangely enough this hint also work for this game. Only the remakes have been more split over the years for this series

50 - Joe & Mac (I don't think anyone guessed this one but I posted it already on the main thingie.)
49 - This Controversial entry in a long-running series garnered plenty of criticism, likening it to Britan's exit from the EU
48 - This is the kind of game that's really only worth whatever you put into it and has a HUGE following on Youtube to this day.
47 - This sequel is what reignited my love for Rush and Megadeth.
- Something like 80% of this game's content was completely redone and available to play on two games higher in this list.
46 - This latest entry in a long-running series is a prime example of good platforming game design, but some people find it stale. I think it's possibly the best designed entry into its series (not my fave, though.)
45 - Witty woman goes in, homocidal psycho robot comes out.
44 - This sequel is what re-re ignited my love for Rush and Dream Theater
43 - you can kill Sasquatch, but it's not a triumphant kill.
42 - For the first time in this series, you can play a full campaign as the cooler, redder character instead of the blue boy with lemons. You could play as them in an earlier entry, but selectively.
41 - "un forastero!" *Throws an axe at you*
40 - Inspired by Ninja Gaiden, this linear 8-bit platformer turns into a 16 bit metroidvania around the halfway mark with Link to the Past inspired world swapping.

#37: Fire Emblem Echoes?

#39: I don't know why Supermario added part 2, as the original TLOU was at the end of PS3s life.

Nope

38 - Far Cry 5

37 - ISS 64 (lol)

50 - We're fighting for the last time with the Beam Katana as this series supposedly came to an end.

49 - Here, girlfriend, eat this foul, smelly chunk of raw meat that I've cut out from a giant monster for you.

46 - It's a mech game that came out on a very hot platform and eventually received a port for PC. This game opened up a the E³ 2018 presentation of one certain platform holder.

43 - Cybercop twins that use wild beasts on leashes as partners in battle

41 - Camping, Curry, cuddling, collecting, competitions... and hooligans.

Correct on 38! 37 is a LOT faster than Fifa. This one will need further hints in the days ahead.

"48 - Furries in space, but with on-foot missions." - I think this is Starfox Adventures

OH! 37 is Rocket League?!

That's a lot of hints so I'll try to help you catch up here. I know I have the list, but I haven't seen it yet so I'll just try to guess these before compiling.

48 sounds like Star Fox Assault.
43 is definitely Astral Chain.
40 is, uhhh, Mega Man X? I'm not exactly the most knowledgeable on Mega Man lore.

Alright that's it from me, now to compile your list and surely find out that I knew some more of these (edit: I didn't)