Tough one. REmake 2 was cream of the crop in a lot of ways. However it did have some serious flaws as a true remake, mainly in the A and B campaign structure. In the original, they were two very different paths through the same area. There is even a part where they intersect if played on the right order where Leon has to help Sherry due to radio communication. The stories were actually woven together.
But in REmake 2, it is largely the same game with a few different item locations and Mr X triggers. There are a few variations, but it feels more like a remix with a few side stories than an event that took place alongside your 1st playthrough. You even fight the same final boss in the same spot, which kind of broke the immersion for me (not including the secret boss of course). It did a lot of things right, but you don't have to look hard to see this MAJOR flaw and missed opportunity.
All in all though, my two favorites are still a toss up of RE7 and REmake 2. Having said that, I have yet to play 4 believe it or not.