1 - MGS4 (PS3)
2 - Resident Evil 5 (PS3)
3 - Tekken 6 (PS3)
4 - Soul Calibur IV (PS3)
5 - Silent Hill V (PS3)

Dont know if these games wil be released in 2008:
FF XIII
White Knight Story

10. God of War: Chains of Olympus (PSP
9. Mario Kart Wii (Wii)
8. The Last Remnant (PS3)
7. Infinite Undiscovery (X360)
6. Dragon Quest IX (NDS)
5. Naruto Ultimate Ninja Storm (PS3)
4. Super Smash Brawl Bros (Wii)
3. White Knight Story (PS3)
2. GTA IV (X360)
1. Metal Gear Solid IV (PS3)

1. Lara croft: Underworld
2. Alone in the Dark
3. Alan Wake
4. Aliens: Colonial Marines
5. Dead Space or Dead Island(?2008?/?2009?)

1. MGS4
2. Spore
3. LittleBigPlanet
4. Valkyria Chronicles
5. GTA IV

Oh and if StarCraft II comes out this year, it would be tied with MGS4 at the top.

1. Starcraft II
2. Mario Kart Wii
3. Wii Fit
4. Metal Gear Solid 4
5. Resident Evil 5

 I chose to be optimistic and included it in my list but knowing Blizzard it could come out in 2010.

Well lets see :

Crisis Core ( still not out in the EU )
The force Unleashed
Secret Agent Clank
Ecochrome
Dissidia / Kingdom Hearts BBS ( if they come out this year that is ).

What do you know ... they are all PSP games :P

Spore GTA 4 Gears of war 2 Fable 2 MGS 4 Littlebigplanet Banjo threeie ( is it still called that) Resistance 2 inFamous GTA DLC

1.- GTA IV
2.- MGS4
3.- Killzone 2
4.-Alone in the dark
5.-Prototype

Hmm.

1. Metal Gear Solid 4

2. Resident Evil 5

3. Half-Life 2: Episode 3

4. Starcraft 2

5. Zenoclash

Most anticipated announcements;

1. Diablo III

2. Jak & Daxter: The Lost Frontier

3. Thief 4

4. Dark Messiah (of Might & Magic) sequel (I really enjoyed it).

5. Gothic 4 and The Elder Scrolls V