You have a game called Bloodborne and that's pretty much as close as it gets. 

Yeah, The Surge is solid. It's cool to see a Souls-like in a sci-fi setting. What else? Maybe a Souls-like during the Roman campaigns in Britain? Maybe in what's modern-day Scotland?

That... that was kinda the joke

GIMME BLOODBORNE 2 DAMN IT!!

Have faith in Sony's presentation during E3 and fear the old blood.

We are born of the Blood.

Made Men by the Blood.

Undone by the Blood.

Our Eyes have yet to open.

Fear the Old Blood.

By the gods Lawrence, fear it.

And one of my favourite quotes:

"Grant us eyes, grant us eyes. Plant eyes on our brains, to cleanse our beastly idiocy."

So that we may see that From Software and Japan studio's are working on Bloodborne 2

Bolded: That's pretty much Nioh isn't it?

OT: Ancient Mexican (Aztec) gods required sacrifices to mantain their power, so dying over and over again could be turned into an interesting game mechanic/lore element in such game.

they made it. It is a game called Bloodborne.

What I´d really like is a horror sci-fi Souls... it´d take place in a huge derelict spacecraft, with the levels cleverly interconnected like the world of Lordran in Dark Souls 1, while also borrowing from H. R. Giger designs

Since Nioh already did Japan I guess the only interesting setting would be Aztec. Africa could be cool too. A lot of deities and lore there.