Since a lot of people are suggesting sequels and existing games, characters, etc. instead of original ideas, I will suggest one of my own.
I'd like to see an open world game set in the Harry Potter universe (or something very similar), and the game would mechanically be similar to Rockstar's Bully, where you have the University (Hogwarts or something similar), the campus, and then the areas around, like a near town, the forbidden forrest, some other cool areas. Would have some RPG elements where you can specialize in different kinds of magic, and of course you could choose to be good, evil or anything inbetween. Would have the different houses, like Griffindor, Slytherin, etc. that you could be sorted into or could choose, and you'd be able to compete with them, in different activities. With some kind of influence meter for your school's house, so creating a sort of turf war between the houses, trying to sabotage them etc.