Bit late on the reply. 

Correct on No. 50!

Incorrect on the other two but close with 48 in that the series started in the same console gen. 

#50 Starquake (guessed by BraLoD)

This games is about as old as mereleasing in 1985  (yes, I know I'm old) . It featured a number of features that made it truly unique for a number of years including an absolutely massive space to explore with an incredible 512 screens, unique locations with teleporters in which you had to discover and remember location codes before you could input them, the ability to create temporary platforms, and the ability to use hoverboards. As a kid, this game really set my imagination off. 

# 49 Bioshock Infinite

The original Bioshock was a great game but always felt a bit claustrophobic in its underwater setting. Infinite took the series to the skies and added elements that transformed the combat from a slow pace of planning and execution to rapid think-on-your-feet action whilst flying from sky rail to sky rail. Elizabeth was both a great character and added an interesting gameplay dynamic. As an allied NPC she was fantastically executed in that you never had to worry about her in combat and added a useful skill throughout the levels. The setting was also beautifully realised creating an incredible environment to explore.

#48 Tomb Raider & Tomb Raider: Anniversary 

Ah, the original Tomb Raider, back when games were making the transition from 2D sprites to fully 3D polygonal environments. This was one of the first games I played where I could explore full 3D environments. The sheer joy of exploring the crumbling ruins of ancient cities in what was for the time, incredible 3D worlds has me yearning to be able to play through it for the first time all over again. The game starts as a relatively basic puzzle adventure but rapidly accelerates as you enter the Lost City for the first time and find yourself up against a T-Rex. Like nearly all games of that era, it hasn't aged well, but Tomb Raider Anniversary was a worthy remake for those who want to give it a try. 

These could be anything, lol.

#48 Legacy of Kain?

#47 Prince of Persia?

Clues:

#47 The game immediately following this one in the franchise featured Tag Teams.

#46 This developer doesn't release many games, but they're just about to release one. This is the last game they made before their new one.

Crash Bandicoot: Warped?

Nope on both.

#48 A bunch of freedom fighters want to overthrow an evil dictator in this futuristic FPS

#47 "Cepatan. Buka pintu!"

48 - No
47 - Yes!

Let me post my hints again.

#45: You are practically given every possible decision in the given situation, but regardless of your decisions, you really do question if "right" and "wrong" should even be considered real concepts...

#44: Costumes galore for beating the game and finding secrets, and a "what if" mode where all the characters have... interesting things to say.

#47 - The fabled and loved Ocarina of Time (3D)

So low! Well, I generally go with the opinion that OoT is one of the weaker entries in the 3D Zelda series, let alone the complete Zelda universe. Boring and useless overworld, tedious puzzles and dungeon designs, unnecessary dialogue or "walls" to enter dungeons, predictable outcomes, lackluster and slow combat... But as much as I can complain, I still spent over 100 hours playing this game, and I will never deny how much of an impact this mess of a game made to the future of gaming (inspiring many modern developers or changing 3D gaming with Z-targeting). 

This was my 2nd 3D Zelda game after Skyward Sword, and I was super excited to get it. I think I set my expectations too high, but even then, many people still consider this one of, if not THE best game of all time, to which I say no-no. It's still a great game with an awesome world, interesting characters, fun gameplay, decent soundtrack. And hey, at least they gave the sages a personality which we can relate to, rather than just making them damsels in distress. The time travelling mechanic is also glorious, making the way we percieve the world very different through sidequests and just how Link is a completely different person in either timeline. 

Again, it's a great game. I believe it didn't age well at all. But I can still enjoy it for all its flaws. And maybe it's because I wasn't "there" to enjoy it, but maybe OoT is/was looked upon as BotW will be for how creative and ambitious it seems.

Hint #46 - Maybe the cutest game of this generation. The game is overshadowed by an ocean of other platformers in my favourite 8th gen system.