Mega Man Legends was the answer for my 46.

Hint for number 45.

This is not current gen. The character you play as is the first in his bloodline.

Theatrhyhtm Final Fantasy? :P

@kupomogli

Could be a number of different games, but my guess is Castlevania: Lament of Innocence.

Also, I'm going to skip on the hint for #45, since I'm already lagging behind and it was a ridiculously convoluted hint. The game is the original Legend of Zelda.

Hint for #44:

In the event of a surprise attack, apply the following stratagem: Turn 180 degrees and perform an orderly retreat. Take refuge within a nearby tent if possible. Expose buttocks if all hope is lost.

Dawn of the Sixth Day: 44 Hints Remaining

Hint for #44: A platformer of rare quality, this masterpiece was the greatest Dole advertisement of all time.

Donkey Kong Country. 

You're correct on Fez, I've always had a soft spot for those kinds of things and like cryptography so it sat better with me.

DKC is correct.

I can see the appeal for Fez - I just would've done some things differently. Oh well.

Correct! Pretty easy hint if you take it literally. Together with that last part of the hint, my avatar also gave it way .

Final Fantasy ... *rolls dice* IX?

Hint for #46:

This N64 racing game belongs to a series that has only appeared on NES, N64, and Wii.

I appear to have fallen back a bit, so let's catch up:

49: Pokemon Gold

48: Ace Attorney: Justice for All

47: Layton and the Curious Village

46: NintendoLand

45: New Super Mario Bros. Wii

44 hint: It's the first, but certainly not the last, visit to the list for this man. It's the story of how a simple, structural part of a metallic chain could defy all odds and become a train conductor.

At least, I think that's what it's about.

Excitebike 64