From all the games that I've played I'd have to go with Ni No Kuni, that game looks amazing and I'd prefer that art style to a realistic one.  Studio Ghibli did an amazing job and I really hope Level 5 decides to make a sequel.  So what game would you guys choose?

Time and Eternity for Ps3. Not the best game, I have never played it, but look it up and you will see why I picked it lol

Afro Samurai had a great art style. Too bad the game itself was meh (much like the show...)

Flower.

can it be an american cartoon?

Every JRPG game made :P

Can't really top Ni no Kuni, with Studio Ghibli behind the art and being a film animation company and all.

Guilty Gear Xrd is looking damn good too (for a fully 3D rendered game). And the animation in Xrd is just phenomenal.

Ni No Kuni; they really hit it out of the park, really get me excited of what JRPG of the more anime-ish type will look like going into next-gen!

Ni No Kuni easily (at least of the JRPGs I've played) has the best anime visuals. Although I do enjoy the Tales series visuals as well.