What game do you want the most this year. For me its either SSBB or Re5 if it comes out this year. Most likely not.

Grand Theft Auto IV would have to be my most anticipated game at this point.

Brawl is a close second though!

brawl, then mariokart wii, then gta 4. but havnt there already been alot of these threads.

in random order

wii fit
brawl
mario kart wii
animal crossing wii
elite beat agents 2 ( hopefully)

Metal Gear Solid 4, and to a certain extent, Mario Kart Wii. Even though I don't own or plan on owning a Wii, I have always loved MK.

in Japan it's DQIX followed by FFXIII

in North America GTAIV and Brawl

in Europe GTAIV and Metal Gear 4
(besides PES 2009 and FIFA 2009)

MGS 4 and Half-Life 2: Episode 3 hands down.
GTA IV and Gran Turismo 5 are also very very high up on the list.

 I forgot about Half-Lif 2:episode 3 me too. 

SSBB first, then MGS4, then GTA4 and at the end MKart

Metal Gear Solid 4 followed by Resident Evil 5.