For me it would have to be between Pokemon Blue/Red or Silver/Gold/Crystal oh and i also wanna say Kirby's Adventure for NES.

Ocarina of time. Easily the best game ever!

Ocarina of Time and Super Mario 64 for a tie! Impossible to decide a victor between those two for me.

Pokemon Heart Gold/Soul Silver

Super Mario World. Still play the game from time to time. The Legend of Zelda: A Link to the Past would be a close second.

Interesting to see a high amount of games mentioned from the GameCube era, still a mystery to me how that brilliant console didnt catch on.

I think its kind of obvious at the minute but Wind Waker.

It might have something to do with being the first Nintendo home console game I owned - but it was (and still is) a brilliant game. Can't wait for Wii U version.

Either Pokemon Firered or Fire Emblem 6 (one with Roy). HM SSBB. I know you meant 1 but Nintendo has a ton of quality hard to single out 1

Mmm would have to be any of the Smash games for multiplayer.

Singleplayer, maybe Mario Galaxy. or the Pokemon games.

Honorable mention Tales of Symphonia! (3rd Party I know)

But I have a feeling many Wii U games will make people's favorites.

Xenoblade Chronicles