jblackmel - for dark souls pvp & great commentary
jon4lakers - tech reviews, mainly for smartphone, tablets etc...
edbassmaster - this guy does hilarious things in public
angryjoeshow - entertaining video game reviews
KOBIBA - makes some of the best guitar covers, lots of gnr
BadLipReading - exactly what it sounds like, great channel
BlendTec - who doesn't like seeing electronics get absolutely destroyed?
quarkology - mentioned above
minutephysics - also mentioned above
acornfilms - funniest video game reviews I've seen on youtube, highly recommended tho he doesn't make vids often

Adam Kokesh - Activism, interviews, and assorted hijinks from an anarcho-capitalist perspective. It's sometimes a little bit on the "stoner libertarian" tip for my taste, but Adam has done some pretty good indie journalism at OWS, the inauguration, and so forth. Somehow, I never get tired of watching stupid people being stupid.

Andy Rehfeldt - A super talented dude who rearranges well known songs in hilarious ways. "Angel of Death (Radio Disney Version)" is probably his finest work, but all of it is amazing!

Classic Game Room - The best game reviews around, period... or it used to be, at least. Then CGR blew up and Mark expanded it too much and got bogged down in all his spinoff channels and having some fucking bimbo (badly) read the gaming news. But thankfully it seems to finally be returning to its roots. I could listen to his voice all day long. <3

Strength Camp - It's about getting strong, duh! True fact: it's not actually a camp, though.

The Subtle Art of Video Game Critique - Not at all subtle, but totally hilarious. The other best gaming reviews around.

Top Dog - Official web home of the real baddest man on the planet.

Wolfgore Show - Without exaggeration, the greatest surrealist genius of our time.

And last but certainly not least:

ArabicBoobsTV - Come on. You knew the weird shit was coming, right?

Channels im subscribed to

New Videos
[The What If Machine]
AnthonyPadilla
BasementAlchemy
brusspup
Bryan Romeo
CamilleandKennerly
collegehumor
communitychannel
DaFrontlineTrooper
dakotalapse
David MeShow
David Sides
DavidMeShowCovers
devinsupertramp
earlyriseband
ERB
FocusDesignINFO
freddiew
happyhour
IanH
ImprovEverywhere
InfectiousDesigner
Josephine Andriani
jwcfree
leanbodylifestyle
lindseystomp
linkinparktv
LisaMalambri
LuieLand
machinima
MachinimaPrime
MagicofRahat
MichaelKoryFitness
MonstercatMedia
Node
OfficialJakeandAmir
ooJLEoo
OwnagePranks
penguinz0
RayWilliamJohnson
ricepiratenewgrounds
Roy Kelly
screwattack
SirPsychoFlea
SirPsychoFlea2
smosh
SmoshGames
swoozie06
TheFineBros
TheRealCoolClub
tobin00
Tobuscus
TobyGames
TobyTurner
Vsauce
walkofftheearth
WonderlandWardrobe
WongFuProductions
xHeather360x

tetraninja- he does walkthroughs of all of the latest games to release.
Halo4follower- does videos on Halo
OmniOmegaOB- Lives in Japan and does various videos on PS Vita and Wii U. (pretty funny guy)
and a few others I would like to mention are TheAlexJonesChannel and thedallascowboyshow.

Added BigThink to my list :)