I guess it could. ACIII and WiiU are the only things (alongside 3ds) that will compete this holiday against COD...

Wish I could vote but there's not a "Hell no!" option.

giving the huge advantage it has over it already, will be hard, but not impossible by any chance. another 5M for the 3ds looks very possible if not more, going by vg numbers in that time gap of past entries cod can get easily to 25M if it has it's usual increment, but i dont know how much can the 3ds boost itself on holidays. So will be a close race.
But not really an interesting one that people really care, since i found comparing hardware and software kind of dumb.

Right, I forgot about it. Halo 4 seems like will reach big numbers.