Since the days of Doom in the early 90s, shooters have been defined by the variety of weapons at the player's disposal. From assault and sniper rifles to flamethrowers and plasma cannons, these weapons have defined the gameplay and competitive experience of their respective games. They have been human or alien technology, big or small, and they've made up some of our greatest memories in gaming. One example I'd like to give is the Lancer from Gears of War:

While it might not stand among the upper echelon of shooter weapons, it has been my personal favorite for years. It's accurate at short to medium range, has great stopping power, and has a CHAINSAW (!!!) when you get into tight spots. It may not be the best at any one aspect, but it's a great all-arond weapon.

So what are some of your favorite guns, weapons, or even vehicles that you remember from shooters?

Mine is the Gewehr 43 from Medal of Honor Airborne and Call of Duty World at War.

It looks something like this in both the games. Sometimes without the sights.

I'm not sure if Saints Row is really a proper shooter, but I have to give props to Volition for the Penetrator in SR: The Third. The way it flops around as you beat someone to death with it is utterly hypnotic.

Gears of War: Retro Lancer
Halo: Well pretty much all guns implemented pre-Reach
Dead Space: Javelin Gun, Contact Beam & one I forgot the name of.

As for vehicles:

Halo: Warthogs
Battlefield: Tanks
Gears: Junker (I loved the feel when driving that thing)

No matter how many crazy guns there are I always love the balance of accuracy, range and power that comes with assault rifles. Shooters are so different, but I find the best strategies often involve having a good close range weapon like a shotgun or heavy machine gun with low accuracy mixed with a good long range gun be it either assault or sniper. That is my strategy to always be prepared for any fight.
Multiplayer is a whole different breed and I usually demand accuracy  in guns when playing games from COD, Halo, Killzone of uncharted.

As far as weird guns, I love the Auger in the resistance series because it has kick ass power, shoots through walls and other objects and it has a limited shield. A really fun gun to switch up from the normal fighting in shooters.

That weapon was awesome.

 My favourite gun in every game though is the Desert Eagle/magnum.

My second would probably either be the Spartan Laser from Halo 3 or the flamethrower.

Singel barrel Doom shotgun. It felt good to wield it well.

All them cool weapons Insomniac thinks up for the Ratchet & Clank series.