Halo 4, screw the next Call of Duty, it will probably suck..

Bioshock Infinite more than anything else, by far.

Also, The Last Guardian, and any first-party Wii U games.

I'm looking forward to a lot more games than I realized until I started making this list. At the very top of the list is of course Diablo III. Max Payne was on my list at one point, but the more I see and hear about the game, the more disappointed I become.

Diablo III
Gravity Daze
Ys Celceta
Time Travelers
Journey
Tales of Graces F
Tales of Xillia
Ni no Kuni
The Last Guardian
Final Fantasy Type-0
Final Fantasy X HD
Zone of the Enders Collection
Silent Hill Collection
Metal Gear Solid Rising

Halo 4

Bioshock, Uncharted GA and Tales of Graces F just to see what the fuss is about

Paper mario, mario tennis, kid icarus, resident revelations, MH3G, animal crossing, The last story, Pandora's tower, rhythm heaven, mario party 9, and a lot of wiiU launch titles!!

Soul Calibur 5

Bioshock Infinite and The Last Guardian.

Halo 4 and ME 3

I'm interested in many games out in 2012 but the top 3 are as follows:

1. Ni no Kuni
2. Journey
3. The Last Guardian

Basically, the "gaming is art" entourage.