I still stand by my prediction that the new home console will at least be mentioned at E3. An announcement of some sort whether its a big reveal or not is another question, however I still think the announcement will be there none the less. As for Wii I expect about 3 titles to be announced that have yet to be officially announced, this could be Pikmin 3, StarFox, F-Zero or it could be another entry in the Wii series which I think is very likely.
Then I'm expecting a bigger unvieling of all the 3DS titles that haven't been released by E3. Alongside another 2 or 3 unnanounced first party titles. Alongside those two or three unnanounced first party titles will be an over whelming wave of new unnannounced 3rd party titles.
I expect 3DS could hit a hundred software titles on the market by the end of the fiscal year in March 2012! So expect lots of games to be shown at E3.
-JC7
"In God We Trust - In Games We Play " - Joel Reimer