Nintendo will announce their next gen Nintendo Home Console that will be slated for a 2012 release.
ALL Three Home Consoles will have $50 Price Cuts MINIMUM
At least 3 new PS3 Exclusives will be announced regardless of whether they release in 2011 or not. Not PS3 and PSN games together. 3 PS3 Exlcusives with retail releases.
The 3DS will sell AT LEAST 15 MIL this year WW (2011 and not Fiscal 2011)
Final Fantasy Versus XIII will have a Solid Release Date by or during TGS 2011 for Japan and a Release Timeframe for the West. Will launch in 2012 in all territories including Japan.
Mass Effect 3 will win more RPG Of the Year Awards than any other RPGs in 2011. Yes that means more than TES V Skyrim.
Starcraft II: Heart of the Swarm will have it's release date announced for 2012 and by buying Diablo III in 2011, you will get some sort of special incentive for HOTS in any form.
PSP 2 will be announced this year slated for a Fall 2011 release with at least 10 Launch Games.
Guild Wars 2 will be the most crititcally acclaimed PC Game of 2011 (METACRITIC WISE).
Bulletstorm will be the best selling New IP of 2011 across all platforms combined. (USING VGC Numbers)
I shall continue to add more when things pop up in my mind.