It's only 2011 but I think I am calling Deus Ex: Human Revolution my game of the decade ... flawless in basically every way aside from small things like the prerendered cutscenes looking like they were lifted from a Gamecube game due to their lack of graphical quality.
Just 1000/1000 so here is some advice for anyone going through it who is worried about Pacifist achievment: I did all of the side quests and had several situations where gang members died when I shot them with tranquilizer rifle and the achievement still popped no problem. I think the best way to play it from a achievement perspective is to do a mixed stealh/stealth combat approach. Try to avoid guards mostly as there are way more than enough to get the combat related achievments ... if one or two are making life difficult for you then it is best to take them out since the environment is loaded with items/hidden routes you can use which are easier to negotiate when there is not the constant fear of getting caught to slow you down. Also, be sure to stockpile a good weapon or two as well as grenades for bosses, and grab the laser rifle when you see it 3/4 of the way through the game as it makes the final boss a joke.
The game leaves me wanting for more which is the best way for a game to end. I hope the DLC they have planned fits in with the spirit of the game and adds to the experience in a meaningful way. Even if they don't add achievements I will buy it regardless.