Super Smash Bros. Brawl - Slightly over 700 Hours.
World of Warcraft - Even though I quit playing it a looooong time ago, I probably managed to crack the 600-hour mark.
Super Smash Bros. Melee - Approx. 500 hours, maybe more.
Mario Kart Wii - Around 450 hours, the last time I checked.
Guild Wars - About 400 hours, I guess.
Super Metroid - Over 300 Hours, at least.
Super Mario Bros. - Same as above.
Warcraft III - Not sure. 250-300, probably.
Super Mario Bros. 3 - Same as above.
Super Street Fighter II - Somewhere between 200 & 300.
Starcraft - Not sure. 200-250, probably.
Street Fighter IV - A bit more than 200 hours.
Final Fantasy III/VII - Almost 200 hours, probably.
Chrono Trigger - Same as above.
Grand Theft Auto: San Andreas - Less than 200 hours, I think, but more than a 100 hours.
Metroid Prime Trilogy - Around a 100, if memory serves.
The Legend of Zelda: Ocarina of Time - Less than a 100.
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PS. Most of these numbers are pure speculation, and I'm probably still forgetting a bunch of games, that I've invested more time in.