No More Heroes. It's easily the most creative IP to come from this generation.

Uncharted and Assassin's Creed are thte only really good ones, though Dragon Age isn't that bad either. And LittleBigPlanet has potential to become something great, it's just not quite there yet.

Uncharted, Uncharted & Uncharted (thanks to Uncharted 2 not the first game).

Littlebigplanet of coure

Assasin's creed 2

Gears of War

Wii series

No More Heroes

Infamous

Red Steel

Condemned, Viva Pinata and Mass Effect.

Wii: Endless Ocean, Muramasa: The Demon Blade, de Blob, Little King's Story, World of Goo*, No More Heroes*

DS: Scribblenauts, Professor Layton, Brain Training, Ace Attorney (western release), Nintendogs (haven't played it but I think it's an excellent execution of an old idea, success and ratings agree)

PS3: Flower, Valkyria Chronicles, Uncharted, Heavenly Sword, LittleBigPlanet (haven't played it, but I think it's a great new IP with wonderful art design)

PSP: Patapon, LocoRoco, Lumines, Half-Minute Hero, Jeanne d'Arc

PC: Mass Effect*, Audiosurf, The Book of Unwritten Tales, Drakensang, Mount & Blade

*listed under the system I bought them for

PSN: Pixeljunk (in particular Monsters and Shooter for me)

PS3: Heavy Rain, Uncharted, Resistance, Little Big Planet, inFamous, 3D Dot Game Heroes

Xbox360: Gears of War, Mass Effect

Wii: ---

PSP: ---

DS: ---

PC: ---

Multiplat: Assassin's Creed, Bioshock

Bioshock

Mass Effect

Motorstorm

Uncharted

infamous 

Batman Arkham Asylum

Wii Sports

Endless Ocean

Trauma Center

Muramasa The Demon Blade

Fragile Dreams

Cave Story

Super Princess Peach

Elite Beat Agents

Lost Winds