I heard a rumor that F-Zero is in the works. So we may hear something about that at E3?

Luigi's Mansion Wii Please!!!

Kirby,Star Fox,F-Zero,Zelda, and Mii's are all great but my most wanted and hoped for E3 game is Pikmin 3 by FAR. A new Star Fox would be cool though. I know its just a remake with controls but I want N.P.C Pikmin 2 in America kind of bad too.

I badly need my FZero fix !!!!

Here's what we are absolutely sure they will have:

Zelda Wii
3DS
Wii Relax
Wii Party

Aside from those, there are a few more titles that we can speculate will be shown:

3DS Software
Pikmin 3 (Miyamoto last said it was in full-time development)
Kirby Wii (It's on the financial report)

Here's some random speculation:

Project Hammer - resurrected now that Wii MotionPlus will allow the mechanics of the game to work. Renamed, re-imagined. Perhaps this is Retro's project.

Luigi's Mansion 2 - There was some speculation on this a while back. Seems like it would be a good game to go with the Vitality Sensor.

Wii Horse/Ride - Nintendo had a patent for some kind of peripheral where you ride a horse. Was it real or just some kind of red herring?

Starfox Wii - There's been so much talk about it. One can only hope.