It's a disadvantage for attach rate (which is why this stat is next to useless), and perhaps a disadvantage because you have to stand out amongst more competing software titles. Other than that, more hardware sales means more software sales.
And if you're only looking at the most successful titles:
PS2: 13 5 million sellers, 5 10 million sellers
Wii:12 5 million sellers, 7 10 million sellers
360: 7 5 million sellers, 1 10 million seller
PS3: 3 5 million sellers, 0 10 million sellers

"The worst part about these reviews is they are [subjective]--and their scores often depend on how drunk you got the media at a Street Fighter event." — Mona Hamilton, Capcom Senior VP of Marketing
*Image indefinitely borrowed from BrainBoxLtd without his consent.