A portion of a Game Informer interview with Suda51...
GI: You've made comments about the No More Heroes series continuing on a new platform. Do you expect to make a No More Heroes 3? And do you think No More Heroes 2 might eventually be rereleased on Xbox 360 like the original in Japan?
Suda51: If there is a chance to continue No More Heroes, I am interested in making NMH3. I personally think that NMH is a game for Wii, so I would be very happy if I could make a game for the Wii’s successor, whenever that might be. I was not involved in the production of the 360 version of NMH1, so I don’t know anything about that.
Full interview here
http://gonintendo.com/viewstory.php?id=114055