Personally I've found caffeine really helps me with games that ask a lot of by reflexes and concentration; I'll drink a coffee before I fire up F Zero GX, for instance.

Do you fellas/fellarettes ever resort to a bit of chemical stimulation to help with a challenging game?

Nope, but sometimes when PC gaming I put on some loud metal to get me pumped up in competitive games.

I smoke weed sometimes. Doesn't make me play any better, but it does make certain games a lot more fun. Epic Yarn is amazing...

Competitive gaming should have random drug testing.

adderall and/or beta blockers can make a significant differnence to concentration and hand movement precision.

(In case you don't think this is a big deal, the Dota and LoL championships have a $1,000,000 first place prize)

No, when I get stuck on a hard level, I watch video guides or give up.

Haha, I bet! Closest I've come is played Rainbow Road drunk. Now that was trippy.

Eversince i replaced weed and cigarettes with energy drinks as my ritual habitual i've used a can everytime i play. With out weed gaming lost it's fun, that is until I found Rockstar. This week I bought a personal iced beverage brewer, so am switching back to natural (coffee).  

But yeah, i think you haven't truly lived until you've played through Zombi U on Red Bull!!!

I like to play games tired, I dont think it helps but I dont get as frustrated at hard parts so it makes it easier to persist through

I get drunk before playing 3D World with my buddies... It makes the trolling  more awesome..

In just 3 days, I will be doing exactly this at my 25th brithday party. ;)