Goes to...
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UNCHARTED 3: DRAKE'S DECEPTION!
See the video here! = http://www.gametrailers.com/video/game-of-game-of-the/725256
The game also won Best Graphics, Best PS3 Game, Best Singleplayer Game, Best Third Person Shooter, Best Platform Exclusive!
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Check out the Official Awards thread for UC3 here = http://gamrconnect.vgchartz.com/thread.php?id=138022&page=1#
(I figured this deserved its own topic though. GT is quite big).
WELL DESERVED! :D