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Probably Resident Evil Requiem.

The game is incredibly good, has great image quality and runs really well on Switch 2. I might declare it my very favorite game in the series if it weren't for that long, extended stretch where you play as Leon and have to get the detonator parts. There are some moments during that are good but a lot of it just dragged on and had some lame moments (like the mortar launching zombies on the roof). The part with Grace getting the batteries when saving Emily drags a bit too, but being constantly chased by Marie kept it scary. Otherwise, the game is fantastic, I really like the story and Grace & Leon as characters are my favorite protagonists in a single Resident Evil game.

I'd also go with RE7 being pretty much tied with Requiem due to its incredible story (best story in the series for me) perfect pacing and flawless performance on Switch 2, but since it's an older game already, Requiem impressed me more upon their Switch 2 debuts. Maybe. (I had never played the DLC for RE7 before, so that made me love it all over again here).

Regarding Nintendo 1st party though... either Bananza or playing Tears at 60fps. Until November 5th, anyway.