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I'm a big fan of the series and you're probably gonna love the 2nd Investigations game, it's a contender for my favourite in the series. I actually played the Investigation games through emulation and used the fan translation for the 2nd one though the collection was announced just half a year later funnily enough.
The only one I haven't played is the Layton cross-over and that one is in an unfortunate place being the only one not officially available on modern platforms. Level-5 needs to port the Layton series to more modern platforms already, they're bringing the upcoming one to Playstation and PC so hopefully that does well enough to encourage them to do that if that isn't already planned since I wanna play through at least some of that series first before checking out the cross-over game.
