The Development of Metroid Prime 4: Beyond — Interview

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Pemalite said:

Do mature ratings really impact sales?

I mean, things might be different here... But when I was a kid I had no issues grabbing a copy of Doom, Quake, Duke Nukem and more.

I mean it won't greatly decrease sales, but it may mean less parents pick it up for their kids, and Metroid is already a niche series with low sales, so given the game is likely among the most expensive Nintendo has ever made, they probably wanted to appeal to the widest audience they could.