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I'm going to define "dead" as "there has been no major new entries released or announced for 10+ years" (barring games that were cancelled). I was going to just say "10+ years with no new entries," but that would include Grand Theft Auto, The Elder Scrolls, etc.

  • Bioshock - Some of the definitive games of the 7th console generation, this series has been relegated to re-releases since 2013. The series sold 43 million units, so it's quite the big series to lie dormant. I'll believe in that new entry they announced in 2019 when I see it.
  • Castlevania
  • Command & Conquer - This was once the face of the RTS genre, and had some pretty popular spinoffs too. Red Alert 3 and C&C4 were released way back in 2008 and 2010, and the series has since consisted of a free-to-play mobile game and a remaster of two mid-90's games.
  • Driver
  • Frogger
  • Guitar Hero - This was at one point one of the biggest series in the world, selling 40 million units in its first four years, but the last entry was back in late 2015.
  • JB Harold - 20 million sales, mostly in just Japan, with no new releases of any sort since 2008.
  • Medal of Honor - These were some of the early big FPS games on consoles, and part of the late-90's-to-early-00's wave of WW2 themed media. Even 2010's reboot had 5+ million sales, a respectable amount. However, the series has been mostly made obsolescent by EA also owning the rights to Battlefield.
  • NBA Live - Prior to the rise of NBA 2K, this was the big basketball game series.
  • Nintendogs - Last seen at the launch of the 3DS in 2011, Nintendogs + cats still sold 4 million copies.
  • Petz - I know virtually nothing about these games, but they apparently sold more than series like Bomberman and Metroid.
  • Rayman - Legends was released in 2013, and despite it being the best-selling Rayman ever, we never got a successor.
  • SimCity - The 2013 reboot was notoriously bad, but it's funny because Cities: Skylines came out two years later and sold 12 million copies.