I actually feel like this generation gave me pretty much all the series shake-ups I'd been wanting; an ambitious 3D Mario in the mould of 64, a fresh new approach to Zelda, a creative new 2D Mario that's not in the tired NSMB style, a 3D Kirby.
I do hope the next Xenoblade or whatever else Monolith Soft is doing next has a different combat system; the current one isn't bad, but it's been the same for 4 games in a row now, I'd like to see them change it up and go with a more action-oriented style next.