The next Atelier game, number 25 in the series.
Dragon Quest 3 Remake slated for release this summer.
Capcom's Ace Attorney 7.
And for some Nintendo flavor in a third party Direct: Koei-Tecmo is developing Xenoblade Warriors that meshes characters and worlds from the three numbered entries together.
Legend11 correctly predicted that GTA IV will outsell Super Smash Bros. Brawl. I was wrong.