I'd like to see them expand the VR aspect from Labo VR, it felt like Nintendo genuinely had a ton of ideas in that game that it was almost overflowing with content.
Which it won't match a really good VR headset, if Switch 2 has a 1080p screen it should be able to do something a fair bit better than the Switch 1 did with Labo VR. Should be enough to have optional VR play modes for Mario Kart, Metroid Prime 4, etc. etc.