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S.Peelman said:

One remains;

11: The big nuisance in each level of this game is also a shooting mini-game.
Hint 2: In the regular levels, the holes that spawn the individual nuisances can be 'deleted' by placing something in front of it and removing it again. It's probably a glitch.
Hint 3: They are a nuisance because they are rodents, and that's not what you want to have running around these kinds of halls.

Oh, that's gotta be Theme Hospital. Brought back memories of exterminating rats with the click of a mouse as they scurry around.