I keep getting thrown off by these lists of nominees because they go by original release date, and these games were released in a time where the North American release was often a year or more after the Japanese release. Like, we didn't even get Final Fantasy until 1990. Doki Doki Panic was a 1987 release in Japan, but SMB2 wasn't released in NA until 1988.
Anyway, my pick is obviously Mega Man, with Mike Tyson's Punch-Out being a very, very close second.
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