There's the top things that I want most from Nintendo:
Pikmin 4
A ambitious Starfox game that looks good
Crash for Smash
A pokemon party game in the same veins of the mini games from pokemon stadium (I know this is a show apart, but a pokemon direct is a given close to Nintendo e3 direct)
What I think that is very likely to be in the presentation:
Zelda BOTW sequel (probably with a release date)
Metroid Prime 4 footage (probably with a release window)
Monolith project trailer
I am terribly to take blind guesses, so I just hope that something from my wishlist come true
We reap what we sow