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For me it's a very close race between TNG, DS9, and Voyager. All three are excellent, and I've watched some episodes over a dozen times.

In the end I think I have to give it to Voyager, though I'm sure the fact that it's the one I watched the most growing up has a lot to do with that. The central plot of crossing an entire unknown quadrant of the galaxy to try to get home was a compelling one, and Seven and the Doctor are two of my absolute favourite characters in any TV show. In addition to being drop dead gorgeous, Seven was just so damn relatable to me, as someone who didn't really understand human social codes or indeed herself, and struggled to fit in and interact with others. That basically sums up my own life as an autistic.